Schwann Cell and Axon Electrical Potential Differences
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چکیده
منابع مشابه
Schwann Cell and Axon Electrical Potential Differences
In fifty-seven resting nerve fibers of the squid Sepioteuthis sepioidea impaled from outside to inside, three potential difference (PD) levels were recorded. In twelve nerve fibers the position of the tip of the micropipette, when it was recording one of the PD levels, was labeled with carmine, and the minute spot of dye was localized histologically. The first PD level of -10 to -26 mv, was loc...
متن کاملNature of the Schwann Cell Electrical Potential
The effects on the Schwann cell electrical potential of external ionic concentrations and of K-strophanthoside were investigated. Increasing (K)(o) depolarized the cell. The potential is related to the logarithm of (K)(o) in a quasi-linear fashion. The linear portion of the curve has a slope of 45 mv/ten-fold change in (K)(o). Diminutions of (Na)(o) and (Cl)(o) produced only small variations in...
متن کاملMechanisms and roles of axon-Schwann cell interactions.
Gabriel Corfas,1,2 Miguel Omar Velardez,1,2 Chien-Ping Ko,3 Nancy Ratner,4 and Elior Peles5 1Division of Neuroscience, Children’s Hospital, Boston, Massachusetts 02115, 2Department of Neurology, Harvard Medical School, Boston, Massachusetts 02115, 3Section of Neurobiology, Department of Biological Sciences, University of Southern California, Los Angeles, California 90089-2520, 4Department of Pe...
متن کاملTransforming growth factor-beta 1 regulates axon/Schwann cell interactions
We have investigated the potential regulatory role of TGF-beta in the interactions of neurons and Schwann cells using an in vitro myelinating system. Purified populations of neurons and Schwann cells, grown alone or in coculture, secrete readily detectable levels of the three mammalian isoforms of TGF-beta; in each case, virtually all of the TGF-beta activity detected is latent. Expression of T...
متن کاملSchwann cell glycogen selectively supports myelinated axon function.
OBJECTIVE Interruption of energy supply to peripheral axons is a cause of axon loss. We determined whether glycogen was present in mammalian peripheral nerve, and whether it supported axon conduction during aglycemia. METHODS We used biochemical assay and electron microscopy to determine the presence of glycogen, and electrophysiology to monitor axon function. RESULTS Glycogen was present i...
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ژورنال
عنوان ژورنال: Journal of General Physiology
سال: 1963
ISSN: 1540-7748,0022-1295
DOI: 10.1085/jgp.46.5.1047